BSE (Bovine Spongiform Encephalopathy)

Here are failed or at least highly problematic approaches and unsuccessful attempts to treat BSE (Bovine Spongiform Encephalopathy) and Rabies (Rage) – two neurological diseases that, despite intensive research, have remained extremely resistant to classical therapeutic approaches:

2025-06-14

🧠 BSE (Bovine Spongiform Encephalopathy)

A prion-induced breakdown of cerebral order.

❌ Failed Treatment Approaches:

1. Prion Vaccine Development

   • Problem: Prions are misfolded, body's own proteins (e.g., PrP^Sc).

   • The immune system does not recognize them as foreign – or attacks healthy tissue.

   • →

     Autoimmune risk + low efficacy.

2. Antibody-Based Therapies

   • Idea: Antibodies against pathological prion structures.

   • Reality: Antibodies hardly cross the blood-brain barrier.

   • Moreover: prion structures are resistant to enzymatic cleavage.

3. RNA Interference (RNAi) to silence the PrP gene

   • Promising in cell culture models.

   • In vivo however: unexpected neuronal side effects, as the PrP protein likely fulfills still unknown protective functions in the brain.

4. Chaperone-Based Folding Repair

   • Chaperone molecules should reverse misfolding.

   • →

     Result: instability of the entire folding system, triggering cellular stress and apoptosis.

5. Transplantation of healthy nerve cells

   • Hypothesis: Replacing degenerated brain regions.

   • Reality: Reinfection with existing prions, even in an artificial environment.

   • Prions are infectious but not alive – they are almost indestructible.

🧠 Rabies (Rage)

A viral “psychoinfection” with 100% lethality after the onset of symptoms.

❌ Failed Treatment Attempts (after outbreak):

1. Ribavirin & Interferon Combinations

   • Antiviral drugs that could theoretically help.

   • Practice: No measurable effect in the CNS stage, as the virus has already “taken over” the brain.

2. Ketamine + Midazolam Protocols (“Milwaukee Protocol”)

   • Extremely aggressive anesthesia and immune system support.

   • Only documented survivor: Jeanna Giese (2004).

   • All other attempts failed – >20 protocol attempts without success.

   • Criticism: No clinically sound evidence of efficacy.

3. Experimental Immune Boosters + High-Dose Vitamins

   • Various series of trials with vitamin cocktails, B-complexes, NAD+ etc.

   • Result: no significant change in the course of the disease.

4. Vaccination after onset of symptoms

   • Post-exposure prophylaxis (PEP) is only effective before the onset of symptoms.

   • After the appearance of initial symptoms: no longer effective.

🧬 Why do these therapies fail?

🧨 Conclusion: Two Neurological Road Hazards

• BSE is not a classic pathogen but a structure-induced plague of protein logic – insensitive to almost all methods of modern medicine.
• Rabies is an extremely efficient virus with a built-in time limit: once in the brain, there’s no turning back.

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AUTHOR:  THOMAS JAN POSCHADEL